Solid-state NMR spectroscopy insights for resolving different water pools in alginate hydrogels
نویسندگان
چکیده
Alginate hydrogels are versatile self-assembling biocompatible materials with diverse biomedical and food industrial applications, which includes uses in encapsulation, (drug) delivery tissue engineering. Hydrogel formation requires cross-linking, for alginates is often done calcium ions that engage specific interactions the polysaccharide carboxylic acid groups. Water molecules also hydrate these alginate groups fill macropores within hydrogels, implications both mechanical properties cargo encapsulation. Understanding aspects of observation characterization hydrogel waters, how they alginate, macropores. Here we employed solid-state NMR (ssNMR) spectroscopy to detect study water re-hydrated hydrogels. 1 H, 2 13 C magic angle spinning (MAS) relaxation measurements were combined observe alginate. Two different phases detected vary upon gradual (re)hydration These pools differ their chemical shifts properties, reflecting hydration waters directly associated carbohydrate polymers alongside dynamic Thus, ssNMR detects water-filled macropore cross-linking. We cross-linking selectively immobilizes ?-guluronate monosaccharides, but leaves ?-mannuronate units more flexible prone selective re-hydration. experiments can be used probe our understanding design parameters tune performance other applications. • Magic probed molecular Solid-state detecting quantifying Solvent dynamics seen by associate distinct pools. Impact time-dependent compared. Molecular details dynamics, structure re-hydration revealed.
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ژورنال
عنوان ژورنال: Food Hydrocolloids
سال: 2022
ISSN: ['1873-7137', '0268-005X']
DOI: https://doi.org/10.1016/j.foodhyd.2022.107500